Point Lookout is a large swampland unlocked after the purchase of the Point Lookout DLC for Fallout 3. It is based on Point Lookout State Park in Maryland.
Before the war, Point Lookout was still considered one of the most haunted locations in the United States. This is believed to be the case due to the thousands of Confederate prisoners being killed here during the American Civil War. Point Lookout was owned mostly by the Calvert family, who were very influential in the US government. Other areas were generally owned by Constance Blackhall, a man from a rich family who had lived in a Victorian-era mansion in the area for centuries. During the Resource Wars, the US military heightened their presence in the area, setting up locations such as the Turtledove Detention Camp, a place keeping Chinese prisoners; a Naval recruiting center operating in the area; the St. Aubin medical facility, owned by General Atomics International and dedicated to the creation of Robobrains and bio-med gel and a disaster relief outpost that provided information to the populace about the New Plague. During the Sino-American War, the Chinese military sent a submarine to Point Lookout in order to patrol and spy on the area. It became damaged and two spies were sent to destroy it, both failing, one by death and one by capture.
Unlike the Capital Wasteland, Point Lookout's rural location shielded it from atomic destruction, but radiation in the air and water from the Potomac River irradiated the area. This caused the bogs and the surrounding bay to become irradiated. Erosion caused sinkholes and grottoes to open up throughout Point Lookout, as well as swamps rich in natural gases, which cover most of the surface and release explosive methane bubbles. The methane comes from the decomposition of bodies in Civil War graves across the area.
The area is also home to the Swampfolk, a crazed, mutated, highly deformed, inbred people who live all around the swamps. Swamp ghouls and swamplurks are common sights here as well, as they are drawn to the radioactive swamps. Many smugglers also lurk around the area, hoping to find hidden treasures.
- Fallout 3's loading screens describe Point Lookout as "the most haunted place in Maryland."
- There is a Pint-Sized Slasher mask located in room 1K of the Homestead Motel.